In Granny Simulator there are two players, a feeble old grandmother and her lovely grandson. The grandmothers objective is to complete her every day routine while the grandson utilizes uncanny violence and pure brutality to stop her. The grandmother can find items around her house to help fend off her grandson while she completes her objectives.

The grandson can also find objects around the house to throw at his grandmother. Some of the objects are locked in containers that require keys to be opened which can be found around the map.