The Round Up Biactive 1L should be applied to actively growing weeds between April and November. Some weeds, such as nettles, have different timeframes, so please refer to the manufacturer's label for more information. Do not apply manure, fertiliser or pesticides to treated areas until at least 5 days after application. It may take up to 14 days to see the destruction of treated weeds, so do not apply more product before 14 days. Weeds should be thoroughly wetted with the spray solution, but not until there is a run-off. This product kills a broad spectrum of weeds, is cost-effective, long-lasting, and fast-acting.